Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The AICD interactome: implications in neurodevelopment and neurodegeneration

13 Dec 2024

Abstract excerpt

The pathophysiological mechanism involving the proteolytic processing of amyloid precursor protein (APP) and the generation of amyloid plaques is of significant interest in research on Alzheimer's disease (AD). The increasing significance of the downstream AD-related pathophysiological mechanisms has sparked research interest in other products of the APP processing cascades, including the APP intracellular domain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Prion Diseases and Protein Misfolding
Share to S100 Proteins and Annexins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39670668
DOI: 10.1042/bst20241510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The AICD interactome: implications in neurodevelopment and neurodegenerationPMID 39670668Read ↗

Wnt/β-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity.Semantic proximity Read ↗

Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.Semantic proximity Read ↗

Modulation of Gene Expression and Cytoskeletal Dynamics by the Amyloid Precursor Protein Intracellular Domain (AICD)Semantic proximity Read ↗

Small things matter: Implications of APP intracellular domain AICD nuclear signaling in the progression and pathogenesis of Alzheimer’s diseaseSemantic proximity Read ↗

Cellular functions of the amyloid precursor protein from development to dementia.Semantic proximity Read ↗

Amyloid Precursor Protein (APP) controls excitatory/inhibitory synaptic inputs by regulating the transcriptional activator Neuronal PAS Domain Protein 4 (NPAS4)Semantic proximity Read ↗

c-Abl modulates AICD dependent cellular responses: transcriptional induction and apoptosis.Semantic proximity Read ↗

Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in Mice.Semantic proximity Read ↗

Regulation of gene expression by the APP family in the adult cerebral cortexSemantic proximity Read ↗

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domainsSemantic proximity Read ↗

FoxO mediates APP-induced AICD-dependent cell deathSemantic proximity Read ↗

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.