Article
CRISPR-Cas9-Mediated Cytosine Base Editing Screen for the Functional Assessment of CALR Intron Variants in Japanese Encephalitis Virus Replication.
International journal of molecular sciences - 28 Aug 2023
Xiong Youcai, Xi Xiaoning, Xiang Yue, Li Sheng, Liu Hailong, Su Yinyu, He Ruigao, Xiong Chong, Xu Bingrong, Wang Xinyi, Fu Liangliang, Zhao Changzhi, Han Xiaosong, Li Xinyun, Xie Shengsong, Ruan Jinxue
Abstract excerpt
The Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes viral encephalitis in humans, pigs and other mammals across Asia and the Western Pacific. Genetic screening tools such as CRISPR screening, DNA sequencing and RNA interference have greatly improved our understanding of JEV replication and its potential antiviral approaches. However, information on exon and intron mutations associated...
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