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Article

Production of MSTN knockout porcine cells using adenine base-editing-mediated exon skipping.

In vitro cellular & developmental biology. Animal - 1 Apr 2023

Yang Shuai-Peng, Zhu Xiang-Xing, Qu Zi-Xiao, Chen Cai-Yue, Wu Yao-Bing, Wu Yue, Luo Zi-Dan, Wang Xin-Yi, He Chu-Yu, Fang Jia-Wen, Wang Ling-Qi, Hong Guang-Long, Zheng Shu-Tao, Zeng Jie-Mei, Yan Ai-Fen, Feng Juan, Liu Lian, Zhang Xiao-Li, Zhang Li-Gang, Miao Kai, Tang Dong-Sheng

Abstract excerpt

Gene-knockout pigs have important applications in agriculture and medicine. Compared with CRISPR/Cas9 and cytosine base editing (CBE) technologies, adenine base editing (ABE) shows better safety and accuracy in gene modification. However, because of the characteristics of gene sequences, the ABE system cannot be widely used in gene knockout. Alternative splicing of mRNA is an important biological mechanism in...

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PMID: 37099179
DOI: 10.1007/s11626-023-00763-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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