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CRISPR screening of porcine sgRNA library identifies host factors associated with Japanese encephalitis virus replication

14 Oct 2020

Abstract excerpt

Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic flavivirus that causes encephalitis and reproductive disorders in mammalian species. However, the host factors critical for its entry, replication, and assembly are poorly understood. Here, we design a porcine genome-scale CRISPR/Cas9 knockout (PigGeCKO) library containing 85,674 single guide RNAs targeting 17,743 protein-coding genes, 11,053 long...

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PMID: 33057066
DOI: 10.1038/s41467-020-18936-1

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