Article

Base editing generates substantial off-target single nucleotide variants

2018-11-27

Abstract excerpt

Genome editing tools including CRISPR/Cas9 and base editors hold great promise for correcting pathogenic mutations. Unbiased genome-wide off-target effects of the editing in mammalian cells is required before clinical applications, but determination of the extent of off-target effects has been difficult due to the existence of single nucleotide polymorphisms (SNPs) in individuals. Here, we developed a method named...

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Literature Corpus work: 15a94299-f8b4-56f6-b32c-e23d7f9525fa
DOI: 10.1101/480145

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