Article

Adenine Base-Editing-Mediated Exon Skipping Induces Gene Knockout in Cultured Pig Cells

2021-11-12

Abstract excerpt

<title>Abstract</title> <p>Gene-knockout pigs have important applications in agriculture and medicine. Compared with CRISPR/Cas9, Adenine base editor (ABE) convert single A·T pairs to G·C pairs in the genome without generating DNA double-strand breaks, and this method has higher accuracy and biosafety in pig genetic modification. However, the application of ABE in pig gene knockout is limited by protospacer-adjac...

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Literature Corpus work: a22ec08d-d9c3-5df4-a90a-5ce32f5cc3a8
DOI: 10.21203/rs.3.rs-831859/v2

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