Article

Base pair editing of goat embryos: nonsense codon introgression into <i>FGF5</i> to improve cashmere yield

2018-06-15

Abstract excerpt

The ability to alter single bases without DNA double strand breaks provides a potential solution for multiplex editing of livestock genomes for quantitative traits. Here, we report using a single base editing system, Base Editor 3 (BE3), to induce nonsense codons (C-to-T transitions) at four target sites in caprine FGF5. All five progenies produced from microinjected single-cell embryos had alleles with a targete...

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Literature Corpus work: 14d9d9c5-3684-5480-bac0-d642ccc64695
DOI: 10.1101/348441

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