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Article

LRRK2 G2019S mutation contributes to mitochondrial transfer dysfunction in a Drp1-STX17-dependent manner.

Translational neurodegeneration - 8 Dec 2025

Ding Mei, Wang Fen, Jiang Lan-Lan, Ma Chao, Qi Yu-Wan, Liu Jun-Yi, Li Juan, Wang Mei-Xia, Jin Hong, Zhang Jin-Ru, Mao Cheng-Jie, Li Xiao-Kang, Liu Chun-Feng, Cheng Xiao-Yu

Abstract excerpt

BACKGROUND: Previous studies have shown that astrocytes can transfer healthy mitochondria to dopaminergic (DA) neurons, which may serve as an intrinsic neuroprotective mechanism in Parkinson's disease (PD). LRRK2 G2019S is the most common pathogenic mutation associated with PD. In this study, we explored whether mitochondrial transfer is influenced by genetic and environmental factors and whether dysfunction in...

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Identifiers

PMID: 41354840
DOI: 10.1186/s40035-025-00525-1
PMCID: PMC12683823

Genes

STX17
DUSP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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