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Induced pluripotent stem cell‐based modeling of mutant LRRK 2‐associated Parkinson's disease

18 Jan 2019

Abstract excerpt

Recent advances in cell reprogramming have enabled assessment of disease-related cellular traits in patient-derived somatic cells, thus providing a versatile platform for disease modeling and drug development. Given the limited access to vital human brain cells, this technology is especially relevant for neurodegenerative disorders such as Parkinson's disease (PD) as a tool to decipher underlying pathomechanisms....

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PMID: 30656775
DOI: 10.1111/ejn.14345

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