Article
I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.
Human molecular genetics - 1 Sept 2015
Ohta Etsuro, Nihira Tomoko, Uchino Akiko, Imaizumi Yoichi, Okada Yohei, Akamatsu Wado, Takahashi Kayoko, Hayakawa Hideki, Nagai Makiko, Ohyama Manabu, Ryo Masafuchi, Ogino Mieko, Murayama Shigeo, Takashima Akihiko, Nishiyama Kazutoshi, Mizuno Yoshikuni, Mochizuki Hideki, Obata Fumiya, Okano Hideyuki
Abstract excerpt
Leucine-rich repeat kinase 2 (LRRK2) is the causative molecule of the autosomal dominant hereditary form of Parkinson's disease (PD), PARK8, which was originally defined in a study of a Japanese family (the Sagamihara family) harboring the I2020T mutation in the kinase domain. Although a number of reported studies have focused on cell death mediated by mutant LRRK2, details of the pathogenetic effect of LRRK2...
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