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Article

G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice.

Human molecular genetics - 13 Mar 2020

Arbez Nicolas, He XiaoFei, Huang Yong, Ren Mark, Liang Yideng, Nucifora Frederick C, Wang Xiaofang, Pei Zhong, Tessarolo Lino, Smith Wanli W, Ross Christopher A

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disease with a heterogeneous etiology that involves genetic and environmental factors or exogenous. Current LRRK2 PD animal models only partly reproduce the characteristics of the disease with very subtle dopaminergic neuron degeneration. We developed a new model of PD that combines a sub-toxic MPTP insult to the G2019S-LRRK2 mutation. Our newly generated...

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Identifiers

PMID: 31813996
DOI: 10.1093/hmg/ddz271
PMCID: PMC7068031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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