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Article

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.

Cell stem cell - 4 Mar 2011

Nguyen Ha Nam, Byers Blake, Cord Branden, Shcheglovitov Aleksandr, Byrne James, Gujar Prachi, Kee Kehkooi, Schüle Birgitt, Dolmetsch Ricardo E, Langston William, Palmer Theo D, Pera Renee Reijo

Abstract excerpt

Studies of Parkinson's disease (PD) have been hindered by lack of access to affected human dopaminergic (DA) neurons. Here, we report generation of induced pluripotent stem cells that carry the p.G2019S mutation (G2019S-iPSCs) in the Leucine-Rich Repeat Kinase-2 (LRRK2) gene, the most common PD-related mutation, and their differentiation into DA neurons. The high penetrance of the LRRK2 mutation and its clinical...

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Identifiers

PMID: 21362567
DOI: 10.1016/j.stem.2011.01.013
PMCID: PMC3578553

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