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Article

The Differential Influence of Immune, Endocytotic, and Lipid Metabolism Genes on Amyloid Deposition and Neurodegeneration in Subjects at Risk of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Femminella Grazia Daniela, Harold Denise, Scott James, Williams Julie, Edison Paul

Abstract excerpt

BACKGROUND: Over 20 single-nucleotide polymorphisms (SNPs) are associated with increased risk of Alzheimer's disease (AD). We categorized these loci into immunity, lipid metabolism, and endocytosis pathways, and associated the polygenic risk scores (PRS) calculated, with AD biomarkers in mild cognitive impairment (MCI) subjects. OBJECTIVE: The aim of this study was to identify associations between...

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Identifiers

PMID: 33216025
DOI: 10.3233/JAD-200578

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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