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Article

Porcine IKKε is involved in the STING-induced type I IFN antiviral response of the cytosolic DNA signaling pathway

1 Sept 2023

Abstract excerpt

The cyclic GMP–AMP synthase and stimulator of interferon (IFN) genes (cGAS–STING) pathway serves as a crucial component of innate immune defense and exerts immense antiviral activity by inducing the expression of type I IFNs. Currently, STING-activated production of type I IFNs has been thought to be mediated only by TANK-binding kinase 1 (TBK1). Here, we identified that porcine IKKε (pIKKε) is also directly...

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PMID: 37660925
DOI: 10.1016/j.jbc.2023.105213

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