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PRRSV evades innate immune cGAS-STING antiviral function via its Nsp5 to deter STING translocation and activation

21 Aug 2025

Abstract excerpt

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is an important pathogen that seriously endangers pig breeding, causing significant economic losses to the global swine industry. Our previous study found that the DNA sensing innate cGAS-STING signaling pathway plays an important role in inducing interferon (IFN) upon PRRSV infection and inhibition of PRRSV replication. However, the mechanism underlying...

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PMID: 40842188
DOI: 10.1080/21505594.2025.2548625

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