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Article

The STING in the Tail for Cytosolic DNA–Dependent Activation of IRF3

6 Mar 2012

Abstract excerpt

Cytosolic pattern recognition receptors (PRRs) sense intracellular nucleic acids from pathogens such as bacteria and viruses, which leads to the induction of type I interferon (IFN) responses that are essential for an effective immune response. Further, these PRR pathways can be aberrantly activated by self DNA, which leads to autoimmunity. Therefore, understanding the signaling mechanisms that underlie...

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PMID: 22394560
DOI: 10.1126/scisignal.2002919

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