Back to search

Article

African swine fever virus structural protein p17 inhibits cGAS-STING signaling pathway through interacting with STING

2021-06-05

Abstract excerpt

African swine fever (ASF) is highly contagious, causes high mortality in domestic and feral swine, and has a significant economic impact on the global swine industry due to the lack of a vaccine or an effective treatment. African swine fever virus (ASFV) encodes more than 150 polypeptides, which may have intricate and delicate interactions with the host for the benefit of the virus to evade the host’s defenses. Ho...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1f40348c-9615-5112-ab31-2c50ddaebe4d
DOI
10.1101/2021.06.02.446854
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
African swine fever virus structural protein p17 inhibits cGAS-STING signaling pathway through interacting with STINGDOI 10.1101/2021.06.02.446854
The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKεSemantic proximity
African swine fever virus S273R protein antagonizes type I interferon production by interfering with TBK1 and IRF3 interactionSemantic proximity
African swine fever virus MGF360-11L negatively regulates cGAS-STING-mediated inhibition of type I interferon productionSemantic proximity
MGF360-12L of ASFV-SY18 is an immune-evasion protein that inhibits host type I IFN, NF-κB, and JAK/STAT pathwaysSemantic proximity
African swine fever virus MGF505-7R protein interacted with IRF7and TBK1 to inhibit type I interferon productionSemantic proximity
African swine fever virus MGF505-3R inhibits cGAS-STING-mediated IFN-β pathway activation by degrading TBK1Semantic proximity
The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKεSemantic proximity
African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathwaySemantic proximity
African swine fever virus pB318L, a trans-geranylgeranyl-diphosphate synthase, negatively regulates cGAS-STING and IFNAR-JAK-STAT signaling pathwaysSemantic proximity
African Swine Fever Virus Immunosuppression and Virulence Related GeneSemantic proximity
African swine fever virus B175L inhibits the type I interferon pathway by targeting STING and 2′3′-cGAMPSemantic proximity
African swine fever virus I177L induces host inflammatory responses by facilitating the TRAF6-TAK1 axis and NLRP3 inflammasome assemblySemantic proximity
Select a neighboring publication to make it the new centre.