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PRV UL13 inhibits cGAS–STING-mediated IFN-β production by phosphorylating IRF3

15 Sept 2020

Abstract excerpt

Cyclic GMP-AMP (cGAMP) synthase (cGAS) is an intracellular sensor of cytoplasmic viral DNA created during virus infection, which subsequently activates the stimulator of interferon gene (STING)-dependent type I interferon response to eliminate pathogens. In contrast, viruses have developed different strategies to modulate this signalling pathway. Pseudorabies virus (PRV), an alphaherpesvirus, is the causative...

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PMID: 32933581
DOI: 10.1186/s13567-020-00843-4

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