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The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε

19 Apr 2022

Abstract excerpt

African swine fever virus (ASFV), a large and complex cytoplasmic double-stranded DNA virus, has developed multiple strategies to evade the antiviral innate immune responses. Cytosolic DNA arising from invading ASFV is mainly detected by the cyclic GMP-AMP synthase (cGAS) and then triggers a series of innate immune responses to prevent virus invasion. However, the immune escape mechanism of ASFV remains to be...

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PMID: 35437104
DOI: 10.1080/21505594.2022.2065962

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