Article

The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε

2021-06-05

Abstract excerpt

African swine fever virus (ASFV), a large and complex cytoplasmic double-stranded DNA virus, has developed multiple strategies to evade the antiviral innate immune responses. Cytosolic DNA arising from invading ASFV is mainly detected by the cyclic GMP-AMP synthase (cGAS) and then triggers a series of innate immune responses to prevent virus invasion. However, the immune escape mechanism of ASFV remains to be full...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5840463-3afb-52f1-a9c9-43f97cc9ca32
DOI: 10.1101/2021.06.02.446855

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKεDOI 10.1101/2021.06.02.446855Read

The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKεSemantic proximity Read

African swine fever virus S273R protein antagonizes type I interferon production by interfering with TBK1 and IRF3 interactionSemantic proximity Read

African swine fever virus structural protein p17 inhibits cGAS-STING signaling pathway through interacting with STINGSemantic proximity Read

ASFV pD345L protein negatively regulates NF-κB signaling through inhibiting IKK kinase activitySemantic proximity Read

African swine fever virus MGF360-11L negatively regulates cGAS-STING-mediated inhibition of type I interferon productionSemantic proximity Read

African swine fever virus MGF505-3R inhibits cGAS-STING-mediated IFN-β pathway activation by degrading TBK1Semantic proximity Read

African swine fever virus MGF505-7R protein interacted with IRF7and TBK1 to inhibit type I interferon productionSemantic proximity Read

African swine fever virus B175L inhibits the type I interferon pathway by targeting STING and 2′3′-cGAMPSemantic proximity Read

African swine fever virus encoded protein MGF360-13L inhibits cGAS-STING-mediated IFN-I signaling pathwaySemantic proximity Read

Multifunctional pMGF505-7R Is a Key Virulence-Related Factor of African Swine Fever VirusSemantic proximity Read

African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1Semantic proximity Read

African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3Semantic proximity Read