Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1

10 Nov 2021

Abstract excerpt

African swine fever is a severe animal infectious disease caused by African swine fever virus (ASFV), and the morbidity and mortality associated with virulent ASFV isolates are as high as 100%. Previous studies showed that the ability of ASFV to antagonize IFN production is closely related to its pathogenicity. Here, we report that ASFV HLJ/18 infection induced low levels of type I IFN and inhibited...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Disease Management and Epidemiology
Share to interferon and immune responses
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34759016
DOI: 10.4049/jimmunol.2100320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1PMID 34759016Read ↗

African Swine Fever Virus pI215L Inhibits Type I Interferon Signaling by Targeting Interferon Regulatory Factor 9 for Autophagic DegradationSemantic proximity Read ↗

African swine fever virus I177L induces host inflammatory responses by facilitating the TRAF6-TAK1 axis and NLRP3 inflammasome assemblySemantic proximity Read ↗

African Swine Fever Virus L83L Negatively Regulates the cGAS-STING-Mediated IFN-I Pathway by Recruiting Tollip To Promote STING Autophagic DegradationSemantic proximity Read ↗

The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy-Mediated Lysosomal Degradation of TBK1Semantic proximity Read ↗

African swine fever virus MGF505-3R inhibits cGAS-STING-mediated IFN-β pathway activation by degrading TBK1Semantic proximity Read ↗

African swine fever virus MGF505-7R protein interacted with IRF7and TBK1 to inhibit type I interferon productionSemantic proximity Read ↗

The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKεSemantic proximity Read ↗

African swine fever virus MGF360-11L negatively regulates cGAS-STING-mediated inhibition of type I interferon productionSemantic proximity Read ↗

Combinational Deletions of MGF110-9L and MGF505-7R Genes from the African Swine Fever Virus Inhibit TBK1 Degradation by an Autophagy Activator PIK3C2B To Promote Type I Interferon ProductionSemantic proximity Read ↗

African swine fever virus B175L inhibits the type I interferon pathway by targeting STING and 2′3′-cGAMPSemantic proximity Read ↗

Multifunctional pMGF505-7R Is a Key Virulence-Related Factor of African Swine Fever VirusSemantic proximity Read ↗

African swine fever virus pB475L evades host antiviral innate immunity via targeting STAT2 to inhibit IFN-I signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.