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Article

Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies.

Nature genetics - 1 Sept 2023

Salehi Nowbandegani Pouria, Wohns Anthony Wilder, Ballard Jenna L, Lander Eric S, Bloemendal Alex, Neale Benjamin M, O'Connor Luke J

Abstract excerpt

Linkage disequilibrium (LD) is the correlation among nearby genetic variants. In genetic association studies, LD is often modeled using large correlation matrices, but this approach is inefficient, especially in ancestrally diverse studies. In the present study, we introduce LD graphical models (LDGMs), which are an extremely sparse and efficient representation of LD. LDGMs are derived from genome-wide...

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PMID: 37640881
DOI: 10.1038/s41588-023-01487-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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