Article
Identity-by-descent-based phasing and imputation in founder populations using graphical models.
Genetic epidemiology - 1 Dec 2011
Palin Kimmo, Campbell Harry, Wright Alan F, Wilson James F, Durbin Richard
Abstract excerpt
Accurate knowledge of haplotypes, the combination of alleles co-residing on a single copy of a chromosome, enables powerful gene mapping and sequence imputation methods. Since humans are diploid, haplotypes must be derived from genotypes by a phasing process. In this study, we present a new computational model for haplotype phasing based on pairwise sharing of haplotypes inferred to be Identical-By-Descent (IBD)....
Topics
- Algorithms
- Bayes Theorem
- Computer Graphics
- Computer Simulation
- Genetics, Population
- Haplotypes
- Humans
- Models, Genetic
- Polymorphism, Single Nucleotide
- Scotland