LoGicAl: Local ancestry and genotype calling uncertainty-aware ancestry-specific allele frequency estimation from admixed samples

Abstract excerpt

In admixed groups, it is of interest to estimate allele frequencies of their ancestral contributing populations. These ancestry-specific allele frequencies inform genetic drivers of disease etiologies, facilitate genome-wide association study interpretations, enhance polygenic risk prediction and portability, and provide insights into demographic history. Their estimation leverages inferred locus-specific ancestry...

Topics

Open a Topic to create a Post that cites this publication.

• Algorithms
• Genetic Diseases, Inborn
• Genetics, Medical
• Genetics, Population
• Genome, Human
• Models, Genetic
• Polymorphism, Single Nucleotide
• Software

Identifiers and source

Literature Corpus work

7d02deaf-b4ff-59b7-82bb-296da1e04be3

DOI

10.1101/2025.07.01.662683