Accurate and scalable genome-wide ancestry estimation using haplotype clusters.

Abstract excerpt

Unsupervised genome-wide ancestry estimation in unrelated individuals has been a staple in population and medical genetics for decades, and its importance continues to grow with the increasing number of large genetic cohorts of mixed ancestries. We propose an extension to the hapla framework that scales model-based ancestry estimation to unprecedented sample sizes by leveraging inferred haplotype clusters from...

Topics

• Humans
• Haplotypes
• Polymorphism, Single Nucleotide
• Genome, Human
• Genome-Wide Association Study
• Genetics, Population
• Clustering Algorithms
• Models, Genetic