Article
Identity by descent estimation with dense genome-wide genotype data.
Genetic epidemiology - 1 Sept 2011
Han Lide, Abney Mark
Abstract excerpt
We present a novel method, IBDLD, for estimating the probability of identity by descent (IBD) for a pair of related individuals at a locus, given dense genotype data and a pedigree of arbitrary size and complexity. IBDLD overcomes the challenges of exact multipoint estimation of IBD in pedigrees of potentially large size and eliminates the difficulty of accommodating the background linkage disequilibrium (LD)...
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