Article

Partitioning gene-level contributions to complex-trait heritability by allele frequency identifies disease-relevant genes

2021-08-18

Abstract excerpt

Recent works have shown that SNP-heritability—which is dominated by low-effect common variants—may not be the most relevant quantity for localizing high-effect/critical disease genes. Here, we introduce methods to estimate the proportion of phenotypic variance explained by a given assignment of SNPs to a single gene ( genelevel heritability ). We partition gene-level heritability across minor allele frequency (MA...

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Literature Corpus work: c2f894f0-5007-5a39-8e55-b7a527f38624
DOI: 10.1101/2021.08.17.456722

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