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Article

Genetically Predicted Sex Hormone-Binding Globulin and Bone Mineral Density: A Mendelian Randomization Study.

Calcified tissue international - 1 Mar 2021

Qu Zihao, Jiang Jiuzhou, Yang Fangkun, Huang Jiawei, Zhao Jianqiang, Yan Shigui

Abstract excerpt

Previous observational studies have identified various risk factors associated with the development of osteoporosis, including sex hormone-binding globulin (SHBG). The aim of this study was to determine the potential causal effects of circulating SHBG concentrations on bone mineral density (BMD). Two-sample Mendelian randomization (MR) approach was applied in analyses. From summary-level data of genome-wide...

Topics

Adolescent
Adult
Bone Density
Femur Neck
Genome-Wide Association Study
Humans
Mendelian Randomization Analysis
Middle Aged
Osteoporosis
Polymorphism, Single Nucleotide
Sex Hormone-Binding Globulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Young Adult

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PMID: 33068140
DOI: 10.1007/s00223-020-00770-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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