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Article

Shared genetic basis connects smoking behaviors and bone health: insights from a genome-wide cross-trait analysis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 5 Aug 2024

Qin Chenjiarui, Zhang Wenqiang, Xiao Changfeng, Qu Yang, Xiao Jinyu, Wu Xueyao, Zhang Li, Wang Yutong, He Lin, Zhu Jingwei, Wang Wenzhi, Li Yun, Sun Lei, Jiang Xia

Abstract excerpt

Although the negative association of tobacco smoking with osteoporosis is well-documented, little is known regarding the shared genetic basis underlying these conditions. In this study, we aim to investigate a shared genetic architecture between smoking and heel estimated bone mineral density (eBMD), a reliable proxy for osteoporosis. We conducted a comprehensive genome-wide cross-trait analysis to identify...

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Identifiers

PMID: 38843381
DOI: 10.1093/jbmr/zjae082
PMCID: PMC12102605

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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