Article
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
PLoS genetics - 1 Jan 2012
Coviello Andrea D, Haring Robin, Wellons Melissa, Vaidya Dhananjay, Lehtimäki Terho, Keildson Sarah, Lunetta Kathryn L, He Chunyan, Fornage Myriam, Lagou Vasiliki, Mangino Massimo, Onland-Moret N Charlotte, Chen Brian, Eriksson Joel, Garcia Melissa, Liu Yong Mei, Koster Annemarie, Lohman Kurt, Lyytikäinen Leo-Pekka, Petersen Ann-Kristin, Prescott Jennifer, Stolk Lisette, Vandenput Liesbeth, Wood Andrew R, Zhuang Wei Vivian, Ruokonen Aimo, Hartikainen Anna-Liisa, Pouta Anneli, Bandinelli Stefania, Biffar Reiner, Brabant Georg, Cox David G, Chen Yuhui, Cummings Steven, Ferrucci Luigi, Gunter Marc J, Hankinson Susan E, Martikainen Hannu, Hofman Albert, Homuth Georg, Illig Thomas, Jansson John-Olov, Johnson Andrew D, Karasik David, Karlsson Magnus, Kettunen Johannes, Kiel Douglas P, Kraft Peter, Liu Jingmin, Ljunggren Östen, Lorentzon Mattias, Maggio Marcello, Markus Marcello R P, Mellström Dan, Miljkovic Iva, Mirel Daniel, Nelson Sarah, Morin Papunen Laure, Peeters Petra H M, Prokopenko Inga, Raffel Leslie, Reincke Martin, Reiner Alex P, Rexrode Kathryn, Rivadeneira Fernando, Schwartz Stephen M, Siscovick David, Soranzo Nicole, Stöckl Doris, Tworoger Shelley, Uitterlinden André G, van Gils Carla H, Vasan Ramachandran S, Wichmann H-Erich, Zhai Guangju, Bhasin Shalender, Bidlingmaier Martin, Chanock Stephen J, De Vivo Immaculata, Harris Tamara B, Hunter David J, Kähönen Mika, Liu Simin, Ouyang Pamela, Spector Tim D, van der Schouw Yvonne T, Viikari Jorma, Wallaschofski Henri, McCarthy Mark I, Frayling Timothy M, Murray Anna, Franks Steve, Järvelin Marjo-Riitta, de Jong Frank H, Raitakari Olli, Teumer Alexander, Ohlsson Claes, Murabito Joanne M, Perry John R B
Abstract excerpt
Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 individuals from...
