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Article

Dissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk.

British journal of cancer - 1 Oct 2023

Zhou Xuan, Xiao Qian, Jiang Fangyuan, Sun Jing, Wang Lijuan, Yu Lili, Zhou Yajing, Zhao Jianhui, Zhang Han, Yuan Shuai, Timofeeva Maria, Spiliopoulou Athina, Mesa-Eguiagaray Ines, Farrington Susan M, Law Philip J, Houlston Richard S, Ding Kefeng, Dunlop Malcolm G, Theodoratou Evropi, Li Xue

Abstract excerpt

BACKGROUND: Tobacco smoking is suggested as a risk factor for colorectal cancer (CRC), but the complex relationship and the potential pathway are not fully understood. METHODS: We performed two-sample Mendelian randomisation (MR) analyses with genetic instruments for smoking behaviours and related DNA methylation in blood and summary-level GWAS data of colorectal cancer to disentangle the relationship....

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Share to Colorectal Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Associations and Epidemiology

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 37608097
DOI: 10.1038/s41416-023-02397-6
PMCID: PMC10576058

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