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Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathways

29 Mar 2020

Abstract excerpt

BACKGROUND: Smoking and alcohol increase risk for colorectal malignancies. However, colorectal cancer (CRC) is a heterogenic disease and associations with the molecular pathological pathways are unclear. METHODS: This population-based case-control study includes 2444 cases with first-diagnosis CRC and 2475 controls. Tumour tissue was analysed for MSI (microsatellite instability), CIMP (CpG island methylator...

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PMID: 32225169
DOI: 10.1038/s41416-020-0803-0

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