Article
Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 4 May 2022
Jordahl Kristina M, Shcherbina Anna, Kim Andre E, Su Yu-Ru, Lin Yi, Wang Jun, Qu Conghui, Albanes Demetrius, Arndt Volker, Baurley James W, Berndt Sonja I, Bien Stephanie A, Bishop D Timothy, Bouras Emmanouil, Brenner Hermann, Buchanan Daniel D, Budiarto Arif, Campbell Peter T, Carreras-Torres Robert, Casey Graham, Cenggoro Tjeng Wawan, Chan Andrew T, Conti David V, Dampier Christopher H, Devall Matthew A, Díez-Obrero Virginia, Dimou Niki, Drew David A, Figueiredo Jane C, Gallinger Steven, Giles Graham G, Gruber Stephen B, Gsur Andrea, Gunter Marc J, Hampel Heather, Harlid Sophia, Harrison Tabitha A, Hidaka Akihisa, Hoffmeister Michael, Huyghe Jeroen R, Jenkins Mark A, Joshi Amit D, Keku Temitope O, Larsson Susanna C, Le Marchand Loic, Lewinger Juan Pablo, Li Li, Mahesworo Bharuno, Moreno Victor, Morrison John L, Murphy Neil, Nan Hongmei, Nassir Rami, Newcomb Polly A, Obón-Santacana Mireia, Ogino Shuji, Ose Jennifer, Pai Rish K, Palmer Julie R, Papadimitriou Nikos, Pardamean Bens, Peoples Anita R, Pharoah Paul D P, Platz Elizabeth A, Potter John D, Prentice Ross L, Rennert Gad, Ruiz-Narvaez Edward, Sakoda Lori C, Scacheri Peter C, Schmit Stephanie L, Schoen Robert E, Slattery Martha L, Stern Mariana C, Tangen Catherine M, Thibodeau Stephen N, Thomas Duncan C, Tian Yu, Tsilidis Konstantinos K, Ulrich Cornelia M, van Duijnhoven Franzel J B, Van Guelpen Bethany, Visvanathan Kala, Vodicka Pavel, White Emily, Wolk Alicja, Woods Michael O, Wu Anna H, Zemlianskaia Natalia, Chang-Claude Jenny, Gauderman W James, Hsu Li, Kundaje Anshul, Peters Ulrike
Abstract excerpt
BACKGROUND: Currently known associations between common genetic variants and colorectal cancer explain less than half of its heritability of 25%. As alcohol consumption has a J-shape association with colorectal cancer risk, nondrinking and heavy drinking are both risk factors for colorectal cancer. METHODS: Individual-level data was pooled from the Colon Cancer Family Registry, Colorectal Transdisciplinary Study,...
