Article
Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 6 Mar 2023
Carreras-Torres Robert, Kim Andre E, Lin Yi, Díez-Obrero Virginia, Bien Stephanie A, Qu Conghui, Wang Jun, Dimou Niki, Aglago Elom K, Albanes Demetrius, Arndt Volker, Baurley James W, Berndt Sonja I, Bézieau Stéphane, Bishop D Timothy, Bouras Emmanouil, Brenner Hermann, Budiarto Arif, Campbell Peter T, Casey Graham, Chan Andrew T, Chang-Claude Jenny, Chen Xuechen, Conti David V, Dampier Christopher H, Devall Matthew A M, Drew David A, Figueiredo Jane C, Gallinger Steven, Giles Graham G, Gruber Stephen B, Gsur Andrea, Gunter Marc J, Harrison Tabitha A, Hidaka Akihisa, Hoffmeister Michael, Huyghe Jeroen R, Jenkins Mark A, Jordahl Kristina M, Kawaguchi Eric, Keku Temitope O, Kundaje Anshul, Le Marchand Loic, Lewinger Juan Pablo, Li Li, Mahesworo Bharuno, Morrison John L, Murphy Neil, Nan Hongmei, Nassir Rami, Newcomb Polly A, Obón-Santacana Mireia, Ogino Shuji, Ose Jennifer, Pai Rish K, Palmer Julie R, Papadimitriou Nikos, Pardamean Bens, Peoples Anita R, Pharoah Paul D P, Platz Elizabeth A, Rennert Gad, Ruiz-Narvaez Edward, Sakoda Lori C, Scacheri Peter C, Schmit Stephanie L, Schoen Robert E, Shcherbina Anna, Slattery Martha L, Stern Mariana C, Su Yu-Ru, Tangen Catherine M, Thomas Duncan C, Tian Yu, Tsilidis Konstantinos K, Ulrich Cornelia M, van Duijnhoven Fränzel J B, Van Guelpen Bethany, Visvanathan Kala, Vodicka Pavel, Cenggoro Tjeng Wawan, Weinstein Stephanie J, White Emily, Wolk Alicja, Woods Michael O, Hsu Li, Peters Ulrike, Moreno Victor, Gauderman W James
Abstract excerpt
BACKGROUND: Tobacco smoking is an established risk factor for colorectal cancer. However, genetically defined population subgroups may have increased susceptibility to smoking-related effects on colorectal cancer. METHODS: A genome-wide interaction scan was performed including 33,756 colorectal cancer cases and 44,346 controls from three genetic consortia. RESULTS: Evidence of an interaction was observed between...
