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Article

Smoking, Genetic Predisposition, and Colorectal Cancer Risk.

Clinical and translational gastroenterology - 1 Mar 2021

Chen Xuechen, Jansen Lina, Guo Feng, Hoffmeister Michael, Chang-Claude Jenny, Brenner Hermann

Abstract excerpt

INTRODUCTION: Smoking and genetic predisposition are established risk factors for colorectal cancer (CRC). We aimed to assess and compare their individual and joint impact on CRC risk using the novel approach of genetic risk equivalent (GRE). METHODS: Data were extracted from the Darmkrebs: Chancen der Verhütung durch Screening study, a large population-based case-control study in Germany. A polygenic risk score...

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Identifiers

PMID: 33646204
DOI: 10.14309/ctg.0000000000000317
PMCID: PMC7925134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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