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Article

Systematic Identification and Characterization of Causal Risk Genes Implicated in Colorectal Cancer by Integrating GWAS, eQTL, and mQTL Data.

Current drug targets - 1 Jan 2026

Xu Shuai, Guo Guanglin, Gao Jie, Fang Zhou, Chai Lu, Gao Yuanyuan, Liu Junjie, Wang Jun, Siqinbateer, Zhang Lirong

Abstract excerpt

INTRODUCTION: Knowledge of the mechanisms through which common single-nucleotide polymorphisms (SNPs) modulate colorectal cancer (CRC) susceptibility is central to elucidating the molecular basis of this disease. Genome-wide association studies (GWAS) reveal noncoding SNPs influencing CRC susceptibility, yet their functional mechanisms, particularly through gene expression dysregulation, DNA methylation...

Read the complete abstract on PubMed

Topics

Humans
Genome-Wide Association Study
Colorectal Neoplasms
Quantitative Trait Loci
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

DNA Methylation

Gastrointestinal Microbiome

Mendelian Randomization Analysis

Gene Expression Regulation, Neoplastic

Source

Identifiers

PMID: 41930642
DOI: 10.2174/0113894501444884260130225445

Genes

TF
POU5F1B

Provenance

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