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Article

Smoking metabolic signature modifies the risk of colorectal cancer and interacts with genetic susceptibility: a large-scale prospective cohort study.

BMC cancer - 8 May 2026

Wang Jing, Zhang Jiawei, Wu Zhuoyi, Zhao Yuqiang, Meng Shiyin, Xuan Wenjie, Ni Jing

Abstract excerpt

BACKGROUND: Smoking tobacco is proven to be associated with higher colorectal cancer (CRC) risk. However, the metabolic pathways of smoking and how they relate to CRC risk are unclear. METHODS: A total of 227,898 participants from the UK Biobank were included. A two-stage strategy with a combination of linear regression and Mendelian randomization analysis was employed to identify smoking-related metabolites....

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Identifiers

PMID: 42104324
DOI: 10.1186/s12885-026-16123-x
PMCID: PMC13326479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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