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Article

Frizzled 6 mutation regulates reserpine-induced depression-like behavior and Wnt signaling pathway in mice.

European journal of pharmacology - 15 Oct 2023

Yan Xiaoru, Song Xiaona, Chen Wenlu, Jia Yanhuan, Gao Jiping, Wang Xiaotang, Qin Litao, Xue Rui, Song Guohua

Abstract excerpt

BACKGROUND: Frizzled 6 (Fzd6) is involved in the development of various disorders; however, its role in the etiology of depression remains unclear. We aimed to determine the potential regulatory mechanisms of Fzd6 as a Wnt receptor in depression. METHODS: Mice were divided into four groups: wild-type control (Fzd6WT-control), Fzd6 mutant control (Fzd6Q152E-control), wild-type reserpine (Fzd6WT-reserpine), and...

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PMID: 37597646
DOI: 10.1016/j.ejphar.2023.175996

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