Article
Paternal nicotine exposure defines different behavior in subsequent generation via hyper-methylation of mmu-miR-15b.
Scientific reports - 4 Aug 2017
Dai Jingbo, Wang Zhaoxia, Xu Wangjie, Zhang Meixing, Zhu Zijue, Zhao Xianglong, Zhang Dong, Nie Dongsheng, Wang Lianyun, Qiao Zhongdong
Abstract excerpt
The neurobehavioral effects of paternal smoking and nicotine use have not been widely reported. In the present study, nicotine exposure induced depression in the paternal generation, but reduced depression and promoted hyperactivity in F1 offspring. While this intergenerational effect was not passed down to the F2 generation. Further studies revealed that nicotine induced the down-regulation of mmu-miR-15b...
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