Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression Profiling of a Genetic Animal Model of Depression Reveals Novel Molecular Pathways Underlying Depressive-Like Behaviours

7 Sept 2010

Abstract excerpt

BACKGROUND: The Flinders model is a validated genetic rat model of depression that exhibits a number of behavioural, neurochemical and pharmacological features consistent with those observed in human depression. PRINCIPAL FINDINGS: In this study we have used genome-wide microarray expression profiling of the hippocampus and prefrontal/frontal cortex of Flinders Depression Sensitive (FSL) and control Flinders...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Memory and Neural Mechanisms
Share to Neurotransmitter Receptor Influence on Behavior
Share to Treatment of Major Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20830301
DOI: 10.1371/journal.pone.0012596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression Profiling of a Genetic Animal Model of Depression Reveals Novel Molecular Pathways Underlying Depressive-Like BehavioursPMID 20830301Read ↗

Escitalopram modulates neuron-remodelling proteins in a rat gene-environment interaction model of depression as revealed by proteomics. Part I: genetic background.Semantic proximity Read ↗

The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorderSemantic proximity Read ↗

[Approaches for identifying depression-related genes using animal models].Semantic proximity Read ↗

Modelling the polygenicity and clinical heterogeneity of human depression in mice to identify biomarkers predictive of treatment responseSemantic proximity Read ↗

Modelling the polygenicity and clinical heterogeneity of human depression in mice to identify biomarkers of antidepressant responseSemantic proximity Read ↗

Elevated Brain Fatty Acid Amide Hydrolase Induces Depressive-Like Phenotypes in Rodent Models: A Review.Semantic proximity Read ↗

Gender variation in whole genome sequencing of susceptibility genes in a rat model of depressionSemantic proximity Read ↗

[Approach to depressogenic genes from genetic analyses of animal models].Semantic proximity Read ↗

Are we getting closer to valid translational models for major depression?Semantic proximity Read ↗

Dysregulation of miR-185, miR-193a, and miR-450a in the skin are linked to the depressive phenotype.Semantic proximity Read ↗

Functional interrogation of a depression-related serotonergic SNP, rs6295, using a humanized mouse modelSemantic proximity Read ↗

Whole genome sequencing of nearly isogeneic WMI and WLI inbred rats identifies genes potentially involved in depressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.