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Article

Increased EphA4-ephexin1 signaling in the medial prefrontal cortex plays a role in depression-like phenotype.

Scientific reports - 2 Aug 2017

Zhang Ji-Chun, Yao Wei, Qu Youge, Nakamura Mayumi, Dong Chao, Yang Chun, Ren Qian, Ma Min, Han Mei, Shirayama Yukihiko, Hayashi-Takagi Akiko, Hashimoto Kenji

Abstract excerpt

Accumulating evidence suggests a role of the ephrin receptor EphA4 and the downstream protein ephexin1 in synaptic plasticity, which is implicated in depression. We examined whether EphA4-ephexin1 signaling plays a role in the pathophysiology of depression, and the antidepressant-like effect of EphA4 inhibitor rhynchophylline. We found increased ratios of p-EphA4/EphA4 and p-ephexin1/ephexin1 in the prefrontal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28769056
DOI: 10.1038/s41598-017-07325-2
PMCID: PMC5541046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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