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ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors

10 Dec 2020

Abstract excerpt

Genome-wide association studies uncovered the association of ZNF804A (Zinc-finger protein 804A) with schizophrenia (SZ). In vitro data have indicated that ZNF804A might exert its biological roles by regulating spine and neurite morphogenesis. However, no in vivo data are available for the role of ZNF804A in psychiatric disorders in general, SZ in particular. We generated ZFP804A mutant mice, and they showed...

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PMID: 33303946
DOI: 10.1038/s41380-020-00972-4

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