Article

A habenula-enriched GPCR, GPR151, regulates behavioral sensitivity to inflammation

2026-08-07

Abstract excerpt

<h4>Background</h4> Inflammation-associated depression is a subtype of major depressive disorder that is often resistant to conventional pharmacotherapies, which act in a regionally non-specific manner and therefore also produce unwanted side effects. Here we test GPR151, an orphan GPCR associated with inflammation and highly expressed in the habenula—a region linked to negative valence and depression—as a therap...

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Literature Corpus work: eb1f688f-e66c-5b2a-b9c1-1b2a43d72a80
DOI: 10.64898/2026.08.02.742327

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