Article

Deep learning-based brain transcriptomic signatures associated with the neuropathological and clinical severity of Alzheimer’s disease

2021-06-10

Abstract excerpt

Brain tissue gene expression from donors with and without Alzheimer’s disease (AD) have been used to help inform the molecular changes associated with the development and potential treatment of this disorder. Here, we use a deep learning method to analyze RNA-seq data from 1,114 brain donors from the AMP-AD consortium to characterize post-mortem brain transcriptome signatures associated with amyloid-β plaque, tau...

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Literature Corpus work: dc97ee53-78d4-5f5e-90a0-b1a1b1486178
DOI: 10.1101/2021.06.08.447615

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