Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

doi:10.1038/s41590-023-01588-w

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Article

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Nature immunology - 1 Sept 2023

Zhao Jing Hua, Stacey David, Eriksson Niclas, Macdonald-Dunlop Erin, Hedman Åsa K, Kalnapenkis Anette, Enroth Stefan, Cozzetto Domenico, Digby-Bell Jonathan, Marten Jonathan, Folkersen Lasse, Herder Christian, Jonsson Lina, Bergen Sarah E, Gieger Christian, Needham Elise J, Surendran Praveen, Paul Dirk S, Polasek Ozren, Thorand Barbara, Grallert Harald, Roden Michael, Võsa Urmo, Esko Tonu, Hayward Caroline, Johansson Åsa, Gyllensten Ulf, Powell Nick, Hansson Oskar, Mattsson-Carlgren Niklas, Joshi Peter K, Danesh John, Padyukov Leonid, Klareskog Lars, Landén Mikael, Wilson James F, Siegbahn Agneta, Wallentin Lars, Mälarstig Anders, Butterworth Adam S, Peters James E

Abstract excerpt

Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans). Integration of pQTL data with eQTL and disease...

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PMID: 37563310
DOI: 10.1038/s41590-023-01588-w
PMCID: PMC10457199

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