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Mapping pQTLs of circulating inflammatory proteins identifies drivers of immune-related disease risk and novel therapeutic targets

2023-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Circulating proteins play key roles in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 15,150 participants. We identified 180 pQTLs, of which 50 were novel. Integration of pQTL data with eQTL and dis...

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Identifiers and source

Literature Corpus work
0b2f32b5-d227-51e0-a7e8-e31892e3e6ae
DOI
10.1101/2023.03.24.23287680
Open publication

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Mapping pQTLs of circulating inflammatory proteins identifies drivers of immune-related disease risk and novel therapeutic targetsDOI 10.1101/2023.03.24.23287680
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