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The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases

10 Jan 2025

Abstract excerpt

Circulating cytokines orchestrate immune reactions and are promising drug targets for immune-mediated and inflammatory diseases. Exploring the genetic architecture of circulating cytokine levels could yield key insights into causal mediators of human disease. Here, we performed genome-wide association studies (GWAS) for 40 circulating cytokines in meta-analyses of 74,783 individuals. We detected 359 significant...

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PMID: 39794498
DOI: 10.1038/s42003-025-07453-w

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