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Article

Circulating inflammatory proteins as causal drivers and therapeutic targets in asthma: insights from genetic and pathway-based analyses.

The Journal of asthma : official journal of the Association for the Care of Asthma - 1 Dec 2025

Miao Yiyan, Chen Haihua, Wei Qishu, Yan Kun, Rukonge Praise Audax, Zhang Zhe, Yu Guiping

Abstract excerpt

OBJECTIVE: To identify circulating inflammatory proteins with potential causal roles in asthma development through integrated genetic and pathway-based analyses, and to evaluate their potential as therapeutic targets. METHODS: We used genetically anchored instrumental variables from 180 protein quantitative trait loci (pQTLs) to assess the causal effects of 91 circulating inflammatory proteins on asthma risk,...

Read the complete abstract on PubMed

Topics

Asthma
Humans
Genome-Wide Association Study
Quantitative Trait Loci
Cytokines
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40887455
DOI: 10.1080/02770903.2025.2555292

Genes

ARTN
CCL19
IL18R1
IL33
IL6
LIFR
MMP10
TGFB1

Provenance

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