Article
Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults.
Genome medicine - 8 Jul 2020
Hillary Robert F, Trejo-Banos Daniel, Kousathanas Athanasios, McCartney Daniel L, Harris Sarah E, Stevenson Anna J, Patxot Marion, Ojavee Sven Erik, Zhang Qian, Liewald David C, Ritchie Craig W, Evans Kathryn L, Tucker-Drob Elliot M, Wray Naomi R, McRae Allan F, Visscher Peter M, Deary Ian J, Robinson Matthew R, Marioni Riccardo E
Abstract excerpt
BACKGROUND: The molecular factors which control circulating levels of inflammatory proteins are not well understood. Furthermore, association studies between molecular probes and human traits are often performed by linear model-based methods which may fail to account for complex structure and interrelationships within molecular datasets. METHODS: In this study, we perform genome- and epigenome-wide association...
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