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Article

Genetic associations in ankylosing spondylitis: circulating proteins as drug targets and biomarkers.

Frontiers in immunology - 1 Jan 2024

Zhang Ye, Liu Wei, Lai Junda, Zeng Huiqiong

Abstract excerpt

Background: Ankylosing spondylitis (AS) is a complex condition with a significant genetic component. This study explored circulating proteins as potential genetic drug targets or biomarkers to prevent AS, addressing the need for innovative and safe treatments. Methods: We analyzed extensive data from protein quantitative trait loci (pQTLs) with up to 1,949 instrumental variables (IVs) and selected the top...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38835753
DOI: 10.3389/fimmu.2024.1394438
PMCID: PMC11148386

Genes

MAPK14
AGER
AIF1
ATF6B
C4A
CFB
CLIC1
COL11A2
ERAP1
HSPA1L
IL23R
LILRB3
MICA
MICB
MPIG6B
TNXB
VARS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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